Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia
| Autor: | Pak H. Chan, Juliette Gafni, Hideyuki Kamii, Guo-Yuan Yang, Charles J. Epstein, Liza Reola, Elaine J. Carlson |
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| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Cerebral arteries Ischemia Infarction Mice Transgenic Brain Ischemia Brain ischemia Mice medicine.artery Animals Humans Medicine cardiovascular diseases Stroke Superoxide Dismutase business.industry Cerebral infarction General Neuroscience Cerebral Infarction Cerebral Arteries medicine.disease Phenotype Cerebral blood flow Cerebrovascular Circulation Middle cerebral artery business Neuroscience |
| Zdroj: | NeuroReport. 5:293-296 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199312000-00028 |
| Popis: | Using a mouse model with intraluminal blockade of the middle cerebral artery (MCA) which produced both cortical and striatal infarction, the effect that superoxide radicals have on cerebral infarction, local cerebral blood flow, and neurological deficits after 24 h of permanent focal cerebral ischemia in transgenic mice (Tg) overexpressing human CuZn-superoxide dismutase (SOD-1) was examined. There were no difference between SOD-1 Tg mice and non-Tg littermates observed in the infarct areas of brain slices, the infarct volume, the local cerebral blood flow, or the neurological deficits. These data suggest that pre-existing high levels of antioxidant enzyme failed to provide neuronal protection against permanent focal cerebral ischemia. |
| Databáze: | OpenAIRE |
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