Lymphatic vessels and related factors in adenoid cystic carcinoma of the salivary gland
| Autor: | Soichi Iwai, Mitsunobu Kishino, Mitsuhiro Nakazawa, Gentaro Fujita, Sunao Sato, Yoshiaki Yura, Satoru Toyosawa, Yuzo Ogawa |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adenoid cystic carcinoma Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D Pathology and Forensic Medicine Lymphatic vessel medicine Carcinoma Humans Lymphangiogenesis Aged Lymphatic Vessels Aged 80 and over Membrane Glycoproteins Salivary gland Reverse Transcriptase Polymerase Chain Reaction business.industry Middle Aged Salivary Gland Neoplasms Vascular Endothelial Growth Factor Receptor-3 medicine.disease Carcinoma Adenoid Cystic Immunohistochemistry Submandibular gland stomatognathic diseases medicine.anatomical_structure Lymphatic system Vascular endothelial growth factor C Lymphatic Metastasis Female business |
| Zdroj: | Modern Pathology. 24:885-891 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.2011.42 |
| Popis: | Adenoid cystic carcinoma of the salivary gland preferentially metastasizes to distant organs. It rarely metastasizes to lymph nodes. Recently, lymphangiogenesis has been associated with lymph node metastasis. Therefore, lymphangiogenesis in adenoid cystic carcinoma was evaluated from the number of lymphatic vessels and the expression of lymphangiogenic factors. Immunohistochemistry and molecular analysis were performed on clinical materials (29 cases for immunohistochemistry and 9 cases for molecular analysis). Normal submandibular gland was used as a negative control of lymphangiogenesis (10 cases for immunohistochemistry and 5 cases for molecular analysis). In adenoid cystic carcinoma, podoplanin-positive lymphatic vessels were small and often constricted, and localized to the tumor periphery. They did not have Ki67-positive endothelial cells. The lymphatic vessel density of the tumor did not exceed that of the salivary gland. By reverse transcriptase-polymerase chain reaction, adenoid cystic carcinoma and the salivary gland expressed vascular endothelial growth factor receptor-3 (VEGFR-3) similarly but VEGF-C and VEGF-D differently. Adenoid cystic carcinoma expressed VEGF-C, whereas the salivary gland expressed both VEGF-C and VEGF-D. VEGF-C was weak in adenoid cystic carcinoma and strong in the salivary gland. Real-time reverse transcriptase-polymerase chain reaction of VEGF-C showed that the ratio of the tumor to the salivary gland was 1 to 30 (P |
| Databáze: | OpenAIRE |
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