The Battle Within: Interactions of Bacteriophages and Bacteria in the Gastrointestinal Tract
| Autor: | Luisa De Sordi, Laurent Debarbieux, Marta Lourenço |
|---|---|
| Přispěvatelé: | Département de Microbiologie - Department of Microbiology, Institut Pasteur [Paris], Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Collège doctoral [Sorbonne universités], Sorbonne Université (SU), Institut Carnot Pasteur Maladie Infectieuse ANR-11-CARN-017-01, M.L. is part of the Pasteur- Paris University (PPU) International PhD Program and has received funding from the Institut Carnot Pasteur Maladie Infectieuse (ANR 11-CARN 017- 01). L.D.S. is funded by a Roux-Cantarini fellowship from the Institut Pasteur (Paris, France). L.D. received support from the DigestScience Foundation (Lille, France)., Cova Rodrigues, Ana, Institut Pasteur [Paris] (IP), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Collège Doctoral |
| Rok vydání: | 2019 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Intestinal physiology In silico Microbiology MESH: Gastrointestinal Microbiome Biological Coevolution 03 medical and health sciences Human health Mice 0302 clinical medicine Virology MESH: Biological Coevolution Animals Humans MESH: Animals Bacteriophages MESH: Bacteriophages MESH: Mice Coevolution 030304 developmental biology Genetics 0303 health sciences Gastrointestinal tract MESH: Humans biology Bacteria Healthy subjects biology.organism_classification Gastrointestinal Microbiome Specific Pathogen-Free Organisms [SDV] Life Sciences [q-bio] MESH: Microbial Interactions MESH: Specific Pathogen-Free Organisms Gastrointestinal Tract MESH: Bacteria Microbial Interactions MESH: Gastrointestinal Tract Parasitology 030217 neurology & neurosurgery |
| Zdroj: | Cell Host & Microbe Cell Host & Microbe, 2019, 25 (2), pp.210-218. ⟨10.1016/j.chom.2019.01.018⟩ |
| ISSN: | 1934-6069 1931-3128 |
| DOI: | 10.1016/j.chom.2019.01.018⟩ |
| Popis: | International audience; The intestinal microbiota is intimately linked to human health. Decoding the mechanisms underlying its stability in healthy subjects should uncover causes of microbiota-associated diseases and pave the way for treatment. Bacteria and bacteriophages (phages) are the most abundant biological entities in the gastrointestinal tract, where their coexistence is dynamic and affixed. Phages drive and maintain bacterial diversity by perpetuating the coevolutionary interactions with their microbial prey. This review brings together recent in silico, in vitro, and in vivo work dissecting the complexity of phage-bacteria interactions in the intestinal microbiota, including coevolution perspectives. We define the types of dynamics encountered in the gastrointestinal tract and the parameters that affect their outcome. The impact of intestinal physiology on phagebacterial coevolution is analyzed in the light of its potential contribution to the relationship between the microbiota and human health. |
| Databáze: | OpenAIRE |
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