Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: a histochemical and immunohistochemical study
| Autor: | Maria Lambropoulou, Nikolas Papadopoulos, Maria Koffa, Theodora-Eleftheria Deftereou, Petros Ypsilantis, Alexandros Papalambros, Iordana Grammatikopoulou, E N Kontomanolis, Ekaterini Chatzaki, Elias Papadopoulos, Olga Pagonopoulou |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Programmed cell death
Histology placenta Congenital disorders Placenta Apoptosis Inflammation Caspase 3 Biochemistry biophysics & molecular biology [F05] [Life sciences] Biology Chorioamnionitis Caspase 8 Pathology and Forensic Medicine Andrology Pregnancy medicine Humans lcsh:QH573-671 Biochimie biophysique & biologie moléculaire [F05] [Sciences du vivant] congenital disorders lcsh:Cytology apoptosis General Medicine medicine.disease Immunohistochemistry chorioamnionitis Abortion Spontaneous Pregnancy Trimester First medicine.anatomical_structure Terminal deoxynucleotidyl transferase Pregnancy Trimester Second Immunology embryonic structures Female medicine.symptom |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 50, Iss 1, Pp 118-124 (2012) Folia Histochemica et Cytobiologica, 50(1), 118-124. (2012). |
| ISSN: | 1897-5631 0239-8508 |
| Popis: | The aim of this study was to investigate the role of apoptotic markers on inflammatory human placentas from spontaneous abortions during the first and second trimester of gestation and compare them to those without inflammation. Paraffin-embedded specimens from 76 placentas were investigated by conventional histology and immunohistochemistry using monoclonal antibodies against M30, Caspase 3, Caspase 8 and Caspase 9, as well as the terminal deoxynucleotidyl tranferase-mediated deoxyuridine triphosphate nick end labeling method. A higher prevalence of expression of apoptotic markers (94.4%) was observed in placentas associated with chorioamnionitis in comparison with those without inflammation. Our observations confirm that apoptosis is strikingly prevalent in placentas diagnosed with histologic chorioamnionitis, while the inflammation induces cell death. © Polish Society for Histochemistry and Cytochemistry. |
| Databáze: | OpenAIRE |
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