Alterations in platelet aggregation associated with adjuvant arthritis in rats
| Autor: | H. B. Lassman, R.E. Kirby, W. J. Novick |
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| Rok vydání: | 1974 |
| Předmět: |
Time Factors
Platelet Aggregation Platelet aggregation Indomethacin Anti-Inflammatory Agents Arthritis Pharmacology Mycobacterium Platelet Adhesiveness Adjuvants Immunologic medicine Animals Aspirin business.industry Fibrinogen medicine.disease Rats Adenosine Diphosphate Disease Models Animal Phenylbutazone Immunology Female Collagen Adjuvant arthritis business |
| Zdroj: | Pharmacological Research Communications. 6:493-507 |
| ISSN: | 0031-6989 |
| DOI: | 10.1016/s0031-6989(74)80059-7 |
| Popis: | Summary Platelet aggregation is enhanced during the early development of adjuvant-induced arthritis in rats and returns to normal after the syndrome becomes established. Cross-over substitution studies indicate that ADP- and Collagen-induced aggregation are enhanced due to a factor present in the plasma of adjuvant-injected rats. The enhanced aggregation is effectively reduced by known inhibitors of platelet aggregation. |
| Databáze: | OpenAIRE |
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