Characteristic plethysmographic findings in a guinea pig model of COPD
Autor: | José Luis Arreola-Ramírez, Mario H. Vargas, Edgar Ramírez-Ramírez, Jesús Alquicira-Mireles, Armando Torres-Ramírez, Martha Montaño-Ramírez, Carlos Ramos-Abraham, Patricia Segura-Medina, Abraham Cañavera-Constantino |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Clinical Biochemistry Guinea Pigs Tobacco smoke Guinea pig 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Smoke medicine Tidal Volume Plethysmograph Animals EF50 Molecular Biology COPD Lung business.industry Respiration Tobacco Products medicine.disease respiratory tract diseases Respiratory Function Tests Plethysmography Disease Models Animal 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Anesthesia Female business Pulmonary Ventilation Respiratory minute volume |
Zdroj: | Experimental lung research. 43(2) |
ISSN: | 1521-0499 |
Popis: | Long-term exposure to cigarette smoke generates chronic obstructive pulmonary disease (COPD) in guinea pigs, but a comprehensive evaluation of changes in lung function, as assessed by barometric whole body plethysmography (WBP), is lacking.Female guinea pigs were exposed to the smoke of 20 cigarettes/day, 5 days/week, during 10 weeks (COPD group, n = 8), and were compared with unexposed female guinea pigs of the same age (control group, n = 8). WBP was performed in both groups, followed by lung histology.At the end of the exposure period, guinea pigs in the COPD group had higher respiratory frequency, while duty cycle (Ti/Ttot) was unaffected. There was a trend toward minute ventilation (MV) and expiratory flow at the mid-tidal volume (EF50) to be higher in the COPD group. Enhanced pause (Penh) was lower, while time of braking (TB) and time to PEF relative to Te (Rpef) were higher in the COPD group. All guinea pigs exposed to tobacco smoke developed emphysematous lesions in their lungs and gained less body weight than controls.In this COPD model, exposure to cigarette smoke produced changes in WBP characterized by a shallow breathing pattern with decreased Penh and a trend toward increasing EF50 (probably due to decreased elastic recoil), increased TB (suggesting dynamic laryngeal narrowing), and a trend of increasing MV (probably due to a higher metabolic rate). Many of these functional changes resemble those observed in patients with COPD and corroborate the suitability of this guinea pig model for the study of COPD. |
Databáze: | OpenAIRE |
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