Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity:A nationwide cohort study with validation of the SARS-CoV-2 diagnosis
| Autor: | Anna J. M. Aabakke, Tanja G. Petersen, Karen Wøjdemann, Mette H. Ibsen, Fjola Jonsdottir, Elisabeth Rønneberg, Charlotte S. Andersen, Anne Hammer, Tine D. Clausen, Julie Milbak, Lars Burmester, Rikke Zethner, Birgitte Lindved, Annette Thorsen‐Meyer, Mohammed R. Khalil, Birgitte Henriksen, Lisbeth Jønsson, Lise L. T. Andersen, Kamilla K. Karlsen, Monica L. Pedersen, Gitte Hedermann, Marianne Vestgaard, Dorthe Thisted, Agnethe N. Fallesen, Josephine N. Johansson, Ditte C. Møller, Greta Dubietyte, Charlotte B. Andersson, Richard Farlie, Ane‐Kersti Skaarup Knudsen, Lea Hansen, Lone Hvidman, Anne N. Sørensen, Sidsel L. Rathcke, Katrine H. Rubin, Lone K. Petersen, Jan S. Jørgensen, Lone Krebs, Mette Bliddal |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Adult
COVID-19/diagnosis Pregnancy Outcome/epidemiology COVID-19 Testing cohort studies Risk Factors Pregnancy Humans Child Pregnancy Complications Infectious/diagnosis pregnancy outcome SARS-CoV-2 pregnancy complications Infant Newborn Patient Acuity Obstetrics and Gynecology COVID-19 General Medicine Hypertension Pregnancy-Induced Asthma prospective studies Abortion Spontaneous Premature Birth/epidemiology obstetric delivery validation study Female severe acute respiratory syndrome coronavirus 2 |
| Zdroj: | Aabakke, A J M, Petersen, T G, Wøjdemann, K, Ibsen, M H, Jonsdottir, F, Rønneberg, E, Andersen, C S, Hammer, A, Clausen, T D, Milbak, J, Burmester, L, Zethner, R, Lindved, B, Thorsen-Meyer, A, Khalil, M R, Henriksen, B, Jønsson, L, Andersen, L L T, Karlsen, K K, Pedersen, M L, Hedermann, G, Vestgaard, M, Thisted, D, Fallesen, A N, Johansson, J N, Møller, D C, Dubietyte, G, Andersson, C B, Farlie, R, Skaarup Knudsen, A-K, Hansen, L, Hvidman, L, Sørensen, A N, Rathcke, S L, Rubin, K H, Petersen, L K, Jørgensen, J S, Krebs, L & Bliddal, M 2023, ' Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity : A nationwide cohort study with validation of the SARS-CoV-2 diagnosis ', Acta Obstetricia et Gynecologica Scandinavica, vol. 102, no. 3, pp. 282–293 . https://doi.org/10.1111/aogs.14512 Aabakke, A J M, Petersen, T G, Wøjdemann, K, Ibsen, M H, Jonsdottir, F, Rønneberg, E, Andersen, C S, Hammer, A, Clausen, T D, Milbak, J, Burmester, L, Zethner, R, Lindved, B, Thorsen-Meyer, A, Khalil, M R, Henriksen, B, Jønsson, L, Andersen, L L T, Karlsen, K K, Pedersen, M L, Hedermann, G, Vestgaard, M, Thisted, D, Fallesen, A N, Johansson, J N, Møller, D C, Dubietyte, G, Andersson, C B, Farlie, R, Skaarup Knudsen, A-K, Hansen, L, Hvidman, L, Sørensen, A N, Rathcke, S L, Rubin, K H, Petersen, L K, Jørgensen, J S, Krebs, L & Bliddal, M 2023, ' Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity : A nationwide cohort study with validation of the SARS-CoV-2 diagnosis ', Acta Obstetricia et Gynecologica Scandinavica, vol. 102, no. 3, pp. 282-293 . https://doi.org/10.1111/aogs.14512 Aabakke, A J M, Petersen, T G, Wøjdemann, K, Ibsen, M H, Jonsdottir, F, Rønneberg, E, Andersen, C S, Hammer, A, Clausen, T D, Milbak, J, Burmester, L, Zethner, R, Lindved, B, Thorsen-Meyer, A, Khalil, M R, Henriksen, B, Jønsson, L, Andersen, L L T, Karlsen, K K, Pedersen, M L, Hedermann, G, Vestgaard, M, Thisted, D, Fallesen, A N, Johansson, J N, Møller, D C, Dubietyte, G, Andersson, C B, Farlie, R, Skaarup Knudsen, A K, Hansen, L, Hvidman, L, Sørensen, A N, Rathcke, S L, Rubin, K H, Petersen, L K, Jørgensen, J S, Krebs, L & Bliddal, M 2023, ' Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity : A nationwide cohort study with validation of the SARS-CoV-2 diagnosis ', Acta Obstetricia et Gynecologica Scandinavica, vol. 102, no. 3, pp. 282-293 . https://doi.org/10.1111/aogs.14512 |
| Popis: | INTRODUCTION: We identified risk factors and outcomes associated with SARS-CoV-2 infection in pregnancy in a universally tested population according to disease severity and validated information on SARS-CoV-2 during pregnancy in national health registers in Denmark.MATERIAL AND METHODS: Cohort study using data from national registers and medical records including all pregnancies between March 1, 2020 and February 28, 2021. We compared women with a validated positive SARS-CoV-2 test during pregnancy with non-infected pregnant women. Risk factors and pregnancy outcomes were assessed by Poisson and Cox regression models and stratified according to disease severity defined by hospital admission status and admission reason (COVID-19 symptoms or other). Using medical record data on actual period of pregnancy, we calculated predictive values of the SARS-CoV-2 diagnosis in pregnancy in the registers.RESULTS: SARS-CoV-2 infection was detected in 1819 (1.6%) of 111 185 pregnancies. Asthma was associated with infection (relative risk [RR] 1.63, 95% confidence interval [CI] 1.28-2.07). Risk factors for severe COVID-19 disease requiring hospital admission were high body mass index (median ratio 1.06, 95% CI 1.04-1.09), asthma (RR 7.47, 95% CI 3.51-15.90) and gestational age at the time of infection (gestational age 28-36 vs CONCLUSIONS: Women infected with SARS-CoV-2 during pregnancy were at increased risk of hypertensive disorders in pregnancy, early pregnancy loss, preterm delivery and having children small for gestational age. The validity of Danish national registers was acceptable for identification of SARS-CoV-2 infection during pregnancy. |
| Databáze: | OpenAIRE |
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