Efficacy and Long-Term Safety of Everolimus in Pancreatic Neuroendocrine Tumor Associated with Multiple Endocrine Neoplasia Type I: Case Report
| Autor: | Delmar Muniz Lourenço, Rachel P. Riechelmann, Manuel C.D.F. Maia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Multiple Endocrine Neoplasia Type I Pancreatic neuroendocrine tumor Treatment outcome Antineoplastic Agents Neuroendocrine tumors Opportunistic Infections 03 medical and health sciences 0302 clinical medicine Internal medicine Endocrine system Medicine Humans 030212 general & internal medicine Everolimus Longitudinal Studies Pulmonary cryptococcosis business.industry Multiple Endocrine Neoplasia Hematology Middle Aged medicine.disease Pancreatic Neoplasms Neuroendocrine Tumors Treatment Outcome 030220 oncology & carcinogenesis Long term safety business medicine.drug |
| Zdroj: | Oncology research and treatment. 39(10) |
| ISSN: | 2296-5262 |
| Popis: | Background: Approximately 10% of pancreatic neuroendocrine tumors (NET) are associated with familial syndromes, with the most common type being multiple endocrine neoplasia type 1 (MEN-1). However, the available evidence on how to treat NET comes from studies in sporadic NET. Case Report: Here we report the case of a 51-year-old male patient with a metastatic MEN-1-associated pancreatic NET and hypercalcemia related to primary hyperparathyroidism and tumor-secreted parathyroid-related protein. The patient was treated with everolimus, and showed complete resolution of hypercalcemia and tumor control for 3 years when he presented with pulmonary cryptococcosis and disease progression. Conclusion: This case report describes the activity of everolimus in a patient with MEN-1-associated pancreatic NET, its efficacy in treating malignant hypercalcemia associated with NET and the risk of opportunistic infections with prolonged use of this agent. |
| Databáze: | OpenAIRE |
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