Hematologic changes predict clinical outcome in recovered patients with COVID-19

Autor: Jian Mao, Yan Zhu, Rui-Chan Du, Li-Ping Shui, Xiao-Hua Luo, Rong Dai
Rok vydání: 2021
Předmět:
Male
Comorbidity
Gastroenterology
Hemoglobins
0302 clinical medicine
Eosinopenia
Lung
Mean corpuscular volume
media_common
education.field_of_study
Hematology
medicine.diagnostic_test
Convalescence
General Medicine
Middle Aged
Prognosis
Combined Modality Therapy
Basophils
C-Reactive Protein
Treatment Outcome
030220 oncology & carcinogenesis
Hypertension
Female
Original Article
Adult
China
medicine.medical_specialty
2019 coronavirus disease
Anemia
media_common.quotation_subject
Population
03 medical and health sciences
Hematologic
Monocytosis
Internal medicine
Diabetes Mellitus
medicine
Humans
education
Aged
Interleukin-6
SARS-CoV-2
business.industry
Oxygen Inhalation Therapy
COVID-19
medicine.disease
Blood Cell Count
COVID-19 Drug Treatment
Eosinophils
Lymphocytopenia
business
030215 immunology
Zdroj: Annals of Hematology
ISSN: 1432-0584
0939-5555
DOI: 10.1007/s00277-021-04426-x
Popis: 2019 coronavirus disease (COVID-19) presents as a newly recognized pneumonia that has brought about a global pandemic and is increasingly considered as a systemic illness. We investigated the clinical and laboratory features of recovered COVID-19 patients without pre-existing hematologic diseases at Wuhan No. 1 Hospital. Fifty-nine male and 68 female Chinese patients were included with the median age at 64 years in the present study. Eosinopenia (37.80%), monocytosis (51.97%), lymphocytopenia (25.20%), and anemia (51.97%) were the most common hematologic findings in our cohort, particularly in severe or critically ill COVID-19. The levels of changes in leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, platelets, hemoglobin levels, mean corpuscular volume (MCV), and mean cell hemoglobin concentration (MCHC) are overall associated with lung involvement, oxygen demand, and disease activity. However, changes of eosinophils (end hospitalization-baseline) (coefficients = 10.32; 95% CI = 1.03–19.60, P = 0.03) and basophils (Max − Min) (coefficients = 71.43; 95% CI = 8.55–134.31, P = 0.03) were independent predictors of delayed recovery in the hospital by the multivariate analysis in this recovered population. A variety of hematologic changes are associated with the severity and clinical outcome of recovered COVID-19 patients, which warrants further exploration of their underlying mechanisms. Supplementary Information The online version contains supplementary material available at 10.1007/s00277-021-04426-x.
Databáze: OpenAIRE
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