T594M mutation of the beta-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension
| Autor: | Frank B. Micah, J. Plange-Rhule, Yanbin Dong, J. B. Eastwood, N. D. Carter, Isaac Kofi Owusu, A. K. Saggar-Malik, Steve Jeffery, F. P. Cappuccio |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Epithelial sodium channel
Adult Male Population Mutation Missense Physiology Black People Group living Ghana Epithelium Sodium Channels Black Populations Gene Frequency parasitic diseases β subunit London Medicine Humans Genetic Predisposition to Disease Allele education Genetics (clinical) Genetics education.field_of_study business.industry Mean age Amino Acid Substitution Mutation (genetic algorithm) Hypertension Female business |
| Zdroj: | Genetic testing. 6(1) |
| ISSN: | 1090-6576 |
| Popis: | We have tested 186 individuals from Ghana, 95 indigenous and 91 who have settled in the United Kingdom, for the presence of the T594M mutation in the beta-subunit of the epithelial sodium channel, which is associated with hypertension in black populations. The group living in Ghana had a mean age of 27 years and were normotensive, but had an increased frequency of the T allele compared to the London-based population. If this is reflected in larger studies, and the link with hypertension is maintained in the Ghanaian population, this mutation could be a significant cause of hypertension in Ghana. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|