Monomeric Intermediates Formed by Vesiculovirus Glycoprotein during Its Low-pH-induced Structural Transition

Autor: Abbas Abou-Hamdan, Yves Gaudin, Laura Belot, Aurélie A. Albertini
Přispěvatelé: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Rhabdovirus (RHABDO), Département Virologie (Dpt Viro), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
cryo-ET
cryo-electron tomography
Models
Molecular
glycoprotein
Conformational change
VSV
vesicular stomatitis virus
Stereochemistry
[SDV]Life Sciences [q-bio]
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL
membrane fusion
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION
Antiparallel (biochemistry)
Crystallography
X-Ray
ComputingMethodologies_ARTIFICIALINTELLIGENCE
Article
Protein Structure
Secondary
03 medical and health sciences
Viral Proteins
conformational change
Structural Biology
CHAV
Chandipura virus
PDB
Protein Data Bank
TrD
trimerization domain
G
glycoprotein
Molecular Biology
ComputingMilieux_MISCELLANEOUS
ComputingMethodologies_COMPUTERGRAPHICS
Glycoproteins
chemistry.chemical_classification
Fusion
EM
electron microscopy
Chemistry
Lipid bilayer fusion
PHD
pleckstrin homology domain
Vesiculovirus
Hydrogen-Ion Concentration
Virus Internalization
Fusion protein
Influenza
3. Good health
030104 developmental biology
ComputingMethodologies_PATTERNRECOGNITION
Ectodomain
Mutation
Protein Multimerization
Glycoprotein
FD
fusion domain
HA
hemagglutinin
Zdroj: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2018, ⟨10.1016/j.jmb.2018.04.015⟩
Journal of Molecular Biology, 2018, ⟨10.1016/j.jmb.2018.04.015⟩
ISSN: 0022-2836
1089-8638
Popis: Graphical Abstract Unlabelled Image
Highlights • Vesiculovirus G is the prototype of class III viral fusion glycoproteins. • The structures of both G pre- and post-fusion conformation have been determined. • The structure of monomeric intermediates reveals the pathway of the transition. • A fusion-loop-exposing antiparallel dimer may initiate the fusion process. • Those data challenge the current model proposed for viral membrane fusion.
Databáze: OpenAIRE
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