The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
| Autor: | Ryuta Muromoto, Tadashi Matsuda, Tsutomu Honjoh, Shiho Kawakami, Norihiko Ohbayashi, Yuichi Sekine, Osamu Ikeda, Sumihito Togi, Shinya Kamitani |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
STAT3 Transcription Factor
Transcriptional Activation SENP1 viruses SUMO-1 Protein Mutant Biophysics SUMO protein Promyelocytic Leukemia Protein Biology Biochemistry STAT3 Mice Cell Line Tumor Endopeptidases Transcriptional regulation Animals Humans transcriptional regulation RNA Messenger Molecular Biology Regulation of gene expression IL-6 PML LIF Interleukin-6 Tumor Suppressor Proteins Lymphokine Nuclear Proteins virus diseases Cell Biology Neoplasm Proteins Cysteine Endopeptidases SUMO Mutation biology.protein Cancer research Signal transduction Protein Processing Post-Translational Transcription Factors |
| Zdroj: | Biochemical and Biophysical Research Communications. 371:823-828 |
| ISSN: | 0006-291X |
| Popis: | Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect