Cognitive function in idiopathic intracranial hypertension: a prospective case–control study
| Autor: | Birgitte Fagerlund, Hysse B Forchhammer, Rigmor Jensen, Hanne M. Yri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Pseudotumor cerebri medicine.medical_treatment Neuropsychological Tests pseudotumor cerebri Executive Function cognition disorders medicine Humans Prospective Studies Prospective cohort study Intracranial pressure Spatial Memory Rehabilitation medicine.diagnostic_test business.industry Cambridge Neuropsychological Test Automated Battery Research case-control studies Neuropsychology General Medicine Neuropsychological test medicine.disease Memory Short-Term Neurology Cohort Female Intracranial Hypertension business |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Objective To explore the extent and nature of cognitive deficits in patients with idiopathic intracranial hypertension (IIH) at the time of diagnosis and after 3 months of treatment. Design Prospective case–control study. Setting Neurological department, ophthalmological department and a tertiary headache referral clinic at a Danish university hospital. Participants 31 patients with definite IIH referred from June 2011 to February 2013 and included within 1 week of diagnostic intracranial pressure (ICP) measurement. 29 patients completed re-examination at the 3-month follow-up. At the time of testing, none of the patients took medication potentially affecting cognitive function. Controls were 31 healthy age-matched and sex-matched volunteers from the local community. Outcome measures Executive function, working memory, visuospatial memory, processing speed, attention and reaction time assessed by a comprehensive neuropsychological test battery consisting of validated computerised (Cambridge neuropsychological test automated battery) and paper-and-pencil tests. Results Patients with IIH performed significantly worse than controls in four of six cognitive domains (p≤0.02). Deficits were most pronounced in reaction time (1.45 SD below controls 95% CI 2.10 to 0.85) and processing speed (1.48 SD below controls 95% CI 2.08 to 0.81). Despite marked improvement in ICP and headache, re-examination showed persistent cognitive dysfunction 3 months after diagnosis and start of treatment. Conclusions We demonstrate for the first time in a well-defined cohort of patients that IIH may be associated with cognitive dysfunction. This could explain the functional disability of patients with IIH. A focused multidisciplinary approach including neuropsychological rehabilitation, therefore, might be relevant in the treatment of patients with IIH. |
| Databáze: | OpenAIRE |
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