Bioactive lysolipids in cancer and angiogenesis
| Autor: | Yu Hisano, Timothy Hla |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chemokine Angiogenesis Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Movement Sphingosine Neoplasms Animals Humans Pharmacology (medical) Sphingosine-1-phosphate Pharmacology Lipoxin Neovascularization Pathologic biology Cell migration Lipid signaling Cell biology 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein lipids (amino acids peptides and proteins) Lysophospholipids Signal transduction |
| Zdroj: | Pharmacology & Therapeutics. 193:91-98 |
| ISSN: | 0163-7258 |
| Popis: | While normal angiogenesis is critical for development and tissue growth, pathological angiogenesis is important for the growth and spread of cancers by supplying nutrients and oxygen as well as providing a conduit for distant metastasis. The interaction among extracellular matrix molecules, tumor cells, endothelial cells, fibroblasts, and immune cells is critical in pathological angiogenesis, in which various angiogenic growth factors, chemokines, and lipid mediators produced from these cells as well as hypoxic microenvironment promote angiogenesis by regulating expression and/or activity of various related genes. Sphingosine 1-phosphate and lysophosphatidic acid, bioactive lipid mediators which act via specific G protein-coupled receptors, play critical roles in angiogenesis. In addition, other lipid mediators including prostaglandin E2, lipoxin, and resolvins are produced in a stimulus-dependent manner and have pro- or anti-angiogenic effects, presumably through their specific GPCRs. Dysregulated lipid mediator signaling pathways are observed in the contxt of some tumors. This review will focus on LPA and S1P, two bioactive lipid mediators in their regulation of angiogenesis and cell migration that are critical for tumor growth and spread. |
| Databáze: | OpenAIRE |
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