Studies on renal adaptation to altered dietary amino acid intake: reduced renal cortex taurine content increases the Vmax of taurine uptake by brush border membrane vesicles
| Autor: | Russell W. Chesney, Naomi Gusowski, Shermine Dabbagh |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Taurine
medicine.medical_specialty Kidney Cortex Brush border Renal cortex Glycine Biology Kidney chemistry.chemical_compound Internal medicine medicine Animals Ingestion Amino Acids chemistry.chemical_classification Microvilli Rats Inbred Strains Diet Rats Amino acid Kinetics medicine.anatomical_structure Endocrinology chemistry Nephrology Pediatrics Perinatology and Child Health Homeostasis |
| Zdroj: | Pediatric Nephrology. 1:9-15 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/bf00866878 |
| Popis: | Rats were placed on a normal taurine diet (NTD), low taurine diet (LTD) or a high taurine diet (HTD) for 14 days. beta-Alanine was fed to half of the animals in each group and resulted in a lowered renal cortex taurine content. Brush border membrane vesicle (BBMV) uptake of taurine was higher after beta-alanine feeding and was associated with an increase in Vmax of uptake. beta-Alanine feeding to HTD animals also altered the Km of uptake, possibly since the load of sulfur amino acids (6% of diet) was high. As a control, glycine (3%) feeding for 8 days along with each diet did not alter the plasma or renal cortex content; BBMV uptake as well as Km and Vmax of taurine accumulation were minimally altered. Accordingly, ingestion of a non-sulfur-containing alpha-amino acid did not change beta-amino acid transport. This study provides evidence that whole body taurine homeostasis is maintained in the presence of a taurine-depleting agent (beta-alanine feeding) by an increase in the number of Na(+)-taurine uptake sites. |
| Databáze: | OpenAIRE |
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