Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia
| Autor: | Tetsuya Takahashi, Yuji Wada, Yuji Tanaka, Sou Nobukawa, Masato Higashima, Mitsuru Kikuchi, Takashi Goto |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Disease Electroencephalography 03 medical and health sciences 0302 clinical medicine Neuroimaging Physiology (medical) medicine Gamma Rhythm Humans Mechanisms of schizophrenia medicine.diagnostic_test business.industry Middle Aged medicine.disease Sensory Systems 030227 psychiatry Drug-naïve medicine.anatomical_structure Neurology Schizophrenia Case-Control Studies Scalp Biomarker (medicine) Female Neurology (clinical) Beta Rhythm business Neuroscience 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
| Zdroj: | Clinical Neurophysiology. 129:222-231 |
| ISSN: | 1388-2457 |
| Popis: | Objective The “dysconnection hypothesis” has been proposed as a core neural basis for schizophrenia. Although growing neuroimaging-based evidence suggests atypical functional connectivity in patients with schizophrenia, the results are inconsistent and the effects of antipsychotic treatment remain elusive. Methods We performed resting-state electroencephalography (EEG) in 21 drug-naive patients with schizophrenia (14 patients were re-evaluated after administration of antipsychotic treatment) and 31 age-matched healthy control subjects. We estimated functional connectivity, using the phase lag index (PLI), which captures the true synchronization of EEG signals. Results The patients had reduced functional connectivity of the beta band across frontal regions and of the gamma band throughout the scalp when compared to the control subjects. In the schizophrenia group, symptom severity did not seem associated with functional connectivity. Antipsychotic treatment led to no alterations in functional connectivity. Conclusions Synchronous activity within and across brain areas over multiple frequencies reflect the integration of various types of information processing. Our findings of abnormal frequency- and region-specific functional connectivity patterns may provide further insight into the “dysconnection hypothesis” of schizophrenia. Significance The PLI may serve as a useful measure for the characterization and understanding of the intrinsic pathophysiological mechanisms of schizophrenia, and as a reliable biomarker for this disease. |
| Databáze: | OpenAIRE |
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