Inhibiting effect of cytotoxic bromine-containing compounds from sponges (Aplysinidae) on Na+-K+-ATPase activity

Autor: Tatyana N. Makarieva, Valentin A. Stonik, I.A. Gorshkova, Boris A Gorshkov
Rok vydání: 1982
Předmět:
Zdroj: Toxicon. 20:1092-1094
ISSN: 0041-0101
DOI: 10.1016/0041-0101(82)90113-1
Popis: —The bromine-containing compounds from sponges of the Aplysinidae family inhibit, in vitro, the Na+-K+-ATPase activity of the rat brain microsomal fraction. The extent of inhibition is dependent on concentration and chemical structure of the compounds. The substances containing the dienone fragment, such as 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-acetamide (IV), 3,5-dibromo-1-acetoxy-4-oxo-2,5-cyclohexadien-1-acetonitrile (V) and 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-ethylacetate (VI), are powerful inhibitors of Na+-K+-ATPase.
Databáze: OpenAIRE