Peritoneal Protein Losses and Cytokine Generation in Automated Peritoneal Dialysis with Combined Amino Acids and Glucose Solutions
| Autor: | Marien W. Fieren, Freek J. Zijlstra, G.R. Swart, T. Rietveld, Hoey Lan Tjiong, J.L.D. Wattimena, Jan G. M. Huijmans |
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| Přispěvatelé: | Internal Medicine, Anesthesiology, Clinical Genetics |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Article Subject Anabolism medicine.medical_treatment Immunology Proinflammatory cytokine Peritoneal dialysis Automation Peritoneum Dialysis Solutions Internal medicine lcsh:Pathology Humans Medicine Dialysis chemistry.chemical_classification Cross-Over Studies Interleukin-6 Tumor Necrosis Factor-alpha business.industry Cell Biology Middle Aged Amino acid C-Reactive Protein Glucose medicine.anatomical_structure Cytokine Endocrinology chemistry Cytokines Female Kidney Diseases Tumor necrosis factor alpha business Peritoneal Dialysis Research Article lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2007 (2007) Mediators of Inflammation. Hindawi Publishing Corporation Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1155/2007/97272 |
| Popis: | Objectives. Protein-energy malnutrition as a consequence of deficient protein intake frequently occurs in peritoneal dialysis (PD) patients. Previously, we showed that peritoneal dialysate containing a mixture of amino acids (AA) and glucose has anabolic effects. However AA-dialysate has been reported to increase intraperitoneal protein and AA losses and the release of proinflammatory cytokines (interleukine-6 (IL-6) and tumor necrosis factor alpha (TNFα)). We investigated the effect of AA plus glucose (AAG) solutions on peritoneal protein losses and cytokine generation.Methods. In 6 patients on standard automated peritoneal dialysis (APD) 12 APD sessions of 6 cycles each were performed during the night using dialysate containing 1.1% AA plus glucose or glucose alone as control. Protein losses and TNFαand IL-6 concentrations were measured in dialysates separately collected from nightly cycling and daytime dwell.Results. The 24 hour-protein losses with AAG (median 6.7 g, range 4.7–9.4 g) were similar to control dialysate (median 6.0 g, range 4.2–9.2 g). Daytime dialysate IL-6 levels were higher after nightly AAG dialysis than after control dialysis (142 pg/ml and 82 pg/ml, respectively,P<.05). TNFαconcentrations were very low.Conclusion. Nightly APD with amino acids containing dialysate was associated with an increase in peritoneal IL-6 generation during the day. The addition of AA to standard glucose dialysis solutions did not induce a significant increase of peritoneal protein losses. |
| Databáze: | OpenAIRE |
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