Blood eosinophil count and FeNO to predict benralizumab effectiveness in real-life severe asthma patients
| Autor: | Satoru Morita, Yutaro Kishimoto, Shingo Takahashi, Hirofumi Watanabe, Hiromasa Nakayasu, Kanami Tamura, Akito Yamamoto, Yuko Tanaka, Toshihiro Masuda, Mika Saigusa, Taisuke Akamatsu, Kazuhiro Asada, Toshihiro Shirai, Keita Hirai, Kyohei Oishi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty Exacerbation medicine.drug_class Antibodies Monoclonal Humanized chemistry.chemical_compound Leukocyte Count Adrenal Cortex Hormones Internal medicine medicine Immunology and Allergy Humans Anti-Asthmatic Agents Asthma medicine.diagnostic_test business.industry Eosinophil medicine.disease Benralizumab Eosinophils medicine.anatomical_structure chemistry Asthma Control Questionnaire Pediatrics Perinatology and Child Health Exhaled nitric oxide Disease Progression Corticosteroid business |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 59(9) |
| ISSN: | 1532-4303 |
| Popis: | Objective Benralizumab is a promising drug for severe uncontrolled asthma. This study aimed to clarify the effectiveness of benralizumab in a real-life setting. Methods Subjects included 24 patients with severe type 2 asthma who received benralizumab between April 2018 and July 2019. Changes in parameters, exacerbation frequency, and oral corticosteroid (OCS) use after 4 and 24 weeks of administration were examined. The parameters included the Global Evaluation of Treatment Effectiveness (GETE) scale, Asthma Control Questionnaire (ACQ), Asthma Control Test (ACT), blood eosinophils, fractional exhaled nitric oxide (FeNO), and spirometry. The response to treatment was defined as follows: for patients with exacerbations or OCS use before treatment initiation, a reduction of ≥50% in exacerbation frequency or OCS use; and for patients without exacerbations or OCS use, an improvement of ≥0.5 in ACQ scores and ≥3 in ACT scores, or of ≥10.38% in FEV1. Results Twenty-one patients completed the treatment for 24 weeks. Excellent and good GETE scales and ACQ and ACT improvement were found in 67% of the patients at 4 weeks, and the effect continued until 24 weeks. The patients' rate with exacerbations was significantly reduced compared to the previous 24 weeks before administration. In 17 patients receiving OCS, the use could be reduced or quit in 14 patients. Overall, 16 patients (76.2%) met the responder definition and could be predicted by the baseline eosinophil count and FeNO levels with the best cutoff values of 100/μL and 40 ppb, respectively. Conclusions Blood eosinophil and FeNO could predict benralizumab effectiveness. |
| Databáze: | OpenAIRE |
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