Organocatalytic Enantioselective Cross-Aldol Reaction of o-Hydroxyarylketones and Trifluoromethyl Ketones
| Autor: | Chao-Shan Da, Hong-Feng Li, Jia-Zhen Zhao, Zhi-Hong Du, Pei Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Trifluoromethyl
010405 organic chemistry organic chemicals Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Aldol reaction Thiourea Yield (chemistry) polycyclic compounds Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 19(10) |
| ISSN: | 1523-7052 |
| Popis: | The enantioselective cross-aldol reaction between o-hydroxyacetophenones and trifluoromethyl ketones catalyzed by chiral thiourea organocatalysts is reported. Gram-scale synthesis of the cross-aldol product was carried out, with no decrease in the yield and enantioselectivity. Furthermore, the cross-aldol products thus prepared were used in the preparation of medicinally interesting 3,5-diaryl-5-trifluoromethyl-2-isoxazoline and β-trifluoromethyl-β-tertiary hydroxy acid ester with high yield and enantiopurity. |
| Databáze: | OpenAIRE |
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