Menstrual cycle perturbation by organohalogens and elements in the Cree of James Bay, Canada
Autor: | Bruce Wainman, Ian D. Martin, Juliana W. Meadows, Edward F. Krieg, James S. Kesner, Evert Nieboer, Leonard J. S. Tsuji |
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Rok vydání: | 2016 |
Předmět: |
Adult
Environmental Engineering Multivariate analysis Health Toxicology and Mutagenesis media_common.quotation_subject Urine 010501 environmental sciences 01 natural sciences Article Selenium 03 medical and health sciences 0302 clinical medicine Blood plasma Humans Environmental Chemistry Medicine Menstrual Cycle Menstrual cycle 0105 earth and related environmental sciences media_common Principal Component Analysis 030219 obstetrics & reproductive medicine Hydrocarbons Halogenated business.industry Confounding Quebec Public Health Environmental and Occupational Health Regression analysis Environmental Exposure Mercury General Medicine General Chemistry Environmental exposure Middle Aged Pollution Confidence interval Trace Elements Bays Environmental chemistry Multivariate Analysis Indians North American Environmental Pollutants Female business Cadmium Demography |
Zdroj: | Chemosphere. 149:190-201 |
ISSN: | 0045-6535 |
Popis: | Persistent organohalogens (POHs) and metals have been linked to alterations in menstrual cycle function and fertility in humans. The Cree First Nations people living near James Bay in Ontario and Quebec, Canada, have elevated levels of POHs, mercury and lead compared to other Canadians. The present study examines the interrelationships between selected POHs and elements on menstrual cycle function in these Cree women. Menstrual cycle characteristics were derived from structured daily diaries and endocrine measurements from daily urine samples collected during one cycle for 42 women age 19-42. We measured 31 POHs in blood plasma and 18 elements in whole blood, for 31 of the participants. POHs and elements detected in ≥ 70% of the participants were transformed by principal component (PC) analysis to reduce the contaminant exposure data to fewer, uncorrelated PCA variables. Multiple regression analysis revealed that, after adjusting for confounders, PC-3 values showed significant negative association with cycle length, after adjusting for confounders (p = 0.002). PC-3 accounted for 9.2% of the variance and shows positive loadings for cadmium, selenium, and PBDE congeners 47 and 153, and a negative loading for copper. Sensitivity analysis of the model to quantify likely effect sizes showed a range of menstrual cycle length from 25.3 to 28.3 days using the lower and upper 95% confidence limits of mean measured contaminant concentrations to predict cycle length. Our observations support the hypothesis that the menstrual cycle function of these women may be altered by exposure to POHs and elements from their environment. |
Databáze: | OpenAIRE |
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