miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma
| Autor: | Ji-ye Feng, Jinbo Wang, Qifeng Zhuo, Mingliang Chen, Li-ping Ying, Weilin Wang, Jianlei Zhang, Gun Chen, Zong-yang Wu |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Down-Regulation Biology Metastasis Cell Movement Cell Line Tumor Internal medicine medicine Humans Aged Cell Proliferation Oncogene Cell growth Liver Neoplasms Cancer Hep G2 Cells General Medicine Middle Aged Cell cycle HCCS Prognosis medicine.disease Molecular medicine digestive system diseases MicroRNAs Hepatocellular carcinoma Trans-Activators Cancer research Female Transcription Factors |
| Zdroj: | Oncology Reports. 33:713-720 |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2014.3642 |
| Popis: | miR-200a suppresses tumor development and progression; however, its role in tumor growth and metastasis of hepatocellular carcinoma (HCC) and the underlying mechanism have not been elucidated. In the present study, we identified that miR-200a was markedly downregulated in HCC and exerted suppressive effects on tumor cell growth and metastasis. We identified that miR-200a suppressed tumor growth and metastasis by directly targeting MACC1. In addition, HCC patients with low miR-200a expression had significantly worse prognosis than those with high expression of miR-200a. These findings suggest that miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation. |
| Databáze: | OpenAIRE |
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