Pulmonary capillary recruitment during airway hypoxia in the dog
| Autor: | W. W. Wagner, L. P. Latham |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pulmonary Circulation
Cardiac output Lung Physiology Capillary action Chemistry Microcirculation Blood Pressure Anatomy Hypoxia (medical) Dogs medicine.anatomical_structure Capillary length Physiology (medical) medicine Animals Vascular Resistance Cardiac Output medicine.symptom Increased pulmonary artery pressure Hypoxia Airway Vasoconstriction |
| Zdroj: | Journal of Applied Physiology. 39:900-905 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1975.39.6.900 |
| Popis: | To study the effect of hypoxia on the pulmonary capillaries, windows were inserted in the chest wall of 9 pentobarbital-anesthetized dogs. A microscope with an image-superimposing device was used to make drawings of the perfused capillaries. Summed lengths of individual perfused capillaries in the drawing were determined with a map-measuring tool. Total capillary length was constant between PaO2 of 160 and 70 Torr. As PaO2 fell below 70 Torr, recruitment of previously unperfused capillaries occurred in every case; at PaO2 of 40 Torr, the total length of perfused capillaries was about 4 times greater than during normoxia. There was no correlation between the recruitment of capillaries and alterations in left atrial pressure, only a weak correlation with cardiac output changes, but a very strong correlation with increased pulmonary artery pressure. This implies that recruitment was probably caused by vasoconstriction within the lung. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|