Detection and significance of anti-HBc in the blood bank; preliminary results of a controlled prospective study
| Autor: | J. N. Katchaki, T. H. Siem, K.H. Brandt, R. Brouwer, M. Van Der Waart |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male HBsAg Adolescent Blood Donors Antibodies Viral Antigen Virology Humans Medicine Prospective Studies Hepatitis B Antibodies Prospective cohort study Aged Hepatitis B Surface Antigens biology business.industry Transfusion Reaction virus diseases Radioimmunoassay Middle Aged Hepatitis B medicine.disease Hepatitis B Core Antigens digestive system diseases Anti hbc Immunology biology.protein Female Antibody business Blood bank |
| Zdroj: | Journal of Virological Methods. 2:119-125 |
| ISSN: | 0166-0934 |
| Popis: | It has been suggested that post-transfusion hepatitis B (PTHB) may occur after transfusion with blood negative for hepatitis B surface antigen (HBsAg) but positive for antibody against hepatitis B core antigen (anti-HBc). We are currently conducting a controlled prospective study of recipients of such blood to investigate this possibility. Blood donors were routinely screened for HBsAg by radioimmunoassay (RIA) and those found negative were tested for anti-HBc by RIA. The HBsAg negative, anti-HBc positive donors were then tested for antibody directed against HBsAg by RIA, antibody directed against hepatitis B ‘e’ antigen by enzyme-immunoassay and for the liver enzymes SGOT and SGPT. Todate, follow-up has been completed in the recipients of 141 anti-HBc positive blood donors and in a control group of the recipients of 141 anti-HBc negative blood donors. All the recipients were bled repeatedly with intervals of 4–5 weeks up to 7 months post-transfusion. Currently, no clear-cut sero con version was observed in recipients of either group for any of the antibody markers of HBV infection. While none of the 141 recipients of anti-HBc negative blood became positive for HBsAg, 3 141 recipients of anti-HBc positive blood acquired HBsAg and developed clinically manifest post-transfusion hepatitis B. |
| Databáze: | OpenAIRE |
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