Effects of locus coeruleus activation and inactivation on hippocampal formation theta rhythm in anesthetized rats
| Autor: | P Klos-Wojtczak, Adam Broncel, Jan Konopacki, Renata Bocian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Theta rhythm Efferent Stimulation Hippocampal formation Hippocampus 03 medical and health sciences Procaine 0302 clinical medicine medicine Animals Anesthetics Local Rats Wistar Theta Rhythm Chemistry Experimental model General Neuroscience Electric Stimulation Rats 030104 developmental biology Infusions Intraventricular Locus coeruleus Locus Coeruleus Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain research bulletin. 162 |
| ISSN: | 1873-2747 |
| Popis: | Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypotheses were tested in the present study: 1/ if the decrease in HPC level of NE is correlated with the desynchronization of HPC field potential, then the inhibition of LC would be expected to abolish HPC type 2 theta rhythm; 2/ if the increase in HPC NE level is correlated with synchronization of HPC field potential, then the stimulation of LC would be expected to produce type 2 theta. The experiments were performed using an experimental model of HPC type 2 theta rhythm recorded in urethanized rats. It was demonstrated that electrical stimulation of LC produced type 2 theta rhythm whereas procaine injection into LC, in contrast, reversibly abolished type 2 theta. The possible relation of type 2 theta rhythm with some disturbances of Alzheimer disease are addressed. |
| Databáze: | OpenAIRE |
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