Erythroid colony formation and erythropoietin activity in mice treated with estradiol benzoate
| Autor: | Clemente Cillo, Maria Cristina Magli, Cesare Peschle, Amato A. Cacciapuoti, F. Pizzella, Federico Lettieri, Gianni Marone |
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| Přispěvatelé: | C., Peschle, M. C., Magli, C., Cillo, F., Lettieri, A., Cacciapuoti, F., Pizzella, Marone, Gianni |
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Dose Estradiol medicine.drug_class Long-term potentiation General Medicine Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology Colony formation chemistry Estrogen Erythropoietin Bone Marrow Internal medicine medicine Estradiol benzoate Erythropoiesis General Pharmacology Toxicology and Pharmaceutics After treatment Spleen Erythropoietin activity medicine.drug |
| Zdroj: | Life sciences. 21(9) |
| ISSN: | 0024-3205 |
| Popis: | In mice administered with estradiol benzoate (EB) at 0.2 or 5 μg dose levels, the number of erythroid colony-forming units (CFU-E) in marrow declines progressively starting from 12 through 48 hr. On the other hand hypoxic erythropoietin (Ep) production, although potentiated in animals primed with relatively large dosages of EB (5–25 μg), is significantly diminished after treatment with lower amounts of estrogen (0.2 μg). In mice primed with large amounts of EB, the enhancement of Ep activity apparently compensates the depleting influence on marrow CFU-E, thus leading to a nearnormal erythroid response to hypoxia. On the other hand, a sharp drop of this parameter is observed in animals primed with the lower dosage (0.2 μg), i.e. the depleting influence on the CFU-E pool is not compensated here by potentiation of the Ep response. |
| Databáze: | OpenAIRE |
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