Immunoglobulin A deficiency following treatment with lamotrigine
| Autor: | Yoshifumi Kawano, Mitsuo Toyoshima, Shinsuke Maruyama, Ryosuke Hanaya, Yasuhiro Okamoto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Immunoglobulin A
Adolescent Lamotrigine Immunoglobulin G Hypogammaglobulinemia 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience medicine Humans Adverse effect Immunodeficiency Epilepsy biology Triazines business.industry Common variable immunodeficiency IgA Deficiency General Medicine medicine.disease Rash Common Variable Immunodeficiency 030228 respiratory system Pediatrics Perinatology and Child Health Immunology biology.protein Anticonvulsants Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain and Development. 38:947-949 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/j.braindev.2016.06.006 |
| Popis: | Lamotrigine (LTG) is an anti-epileptic drug and mood-stabilizing agent, whose adverse effects include skin rash and dizziness. Interactions with the immune system are rare, and only a few cases linking hypogammaglobulinemia to LTG treatment have been previously described. In this report, we describe a case in which a patient developed hypogammaglobulinemia, and a subsequent immunoglobulin A (IgA) deficiency, following LTG treatment. As a result of her immunodeficiency, the patient presented with a severe urinary tract infection and required intravenous immunoglobulin. Serum levels of immunoglobulin G and M had recovered by seven months and one month after the discontinuation of LTG, respectively; however, IgA levels remained low (less than 4mg/dL) two years post-treatment. While previous reports have demonstrated IgA deficiencies in patients prescribed other antiepileptic drugs, this is the first case of an IgA deficiency following LTG administration. |
| Databáze: | OpenAIRE |
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