Drug Therapeutic Failures as a Cause of Admission to an Intensive Care Unit at a University Hospital
| Autor: | Carlos Alberto Calderón-Ospina, Jair Antonio Ruiz-Garzon, Camilo Andrés Rojas-Velandia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
medicine.medical_specialty intensive care units media_common.quotation_subject lcsh:RS1-441 patient admissions Brief Communication 030226 pharmacology & pharmacy Drug-related side effects and adverse reactions law.invention lcsh:Pharmacy and materia medica 03 medical and health sciences Colombian population 0302 clinical medicine law Pharmacovigilance medicine 030212 general & internal medicine media_common business.industry General Medicine University hospital medicine.disease Intensive care unit Confidence interval postmarketing pharmacovigilance Emergency medicine Observational study business Adverse drug reaction product surveillance |
| Zdroj: | Journal of Research in Pharmacy Practice Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario Journal of Research in Pharmacy Practice, Vol 8, Iss 3, Pp 168-172 (2019) |
| ISSN: | 2279-042X 2319-9644 |
| Popis: | Objective: Drug therapeutic failures (TFs) are included in pharmacovigilance reporting, as some authors consider them a type of adverse drug reaction. Given their high frequency in Colombia, we studied their importance as a cause of admission to an intensive care unit (ICU). Methods: This was a cross-sectional observational study. Clinical records of patients who arrived at the emergency service of a third-care level university hospital were reviewed. Information was collected by a resident in clinical toxicology, and each case was validated and analyzed by a research team using the algorithm proposed by Vaca Gonzalez and Schumock and Thornton criteria for preventability to evaluate the existence of possible medication errors. Findings: In total, 697 clinical records were evaluated and 18 patients presented TFs (2.6%, 95% confidence interval 1.5%–4.1%) as the cause of admission to the ICU. The most frequent TFs were seizures (56%) and hypertension (28%). The most commonly associated medications were valproic acid (28%) and losartan (28%). Ten cases (56%) were associated with drug misuse and the same number of cases was preventable, according to Schumock and Thornton criteria. Conclusion: This is the first study assessing TFs as a cause of admission to the ICU in the Colombian population. The frequency of TFs in our study was similar to that described in the literature; being the most common cause the inappropriate drug use, particularly for drugs with complex kinetics, such as antiepileptic drugs. |
| Databáze: | OpenAIRE |
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