Asymptomatic cardiovascular manifestations in diabetes mellitus: Left ventricular diastolic dysfunction and silent myocardial ischemia
| Autor: | Jelena Seferović-Mitrović, Sandra Singh, Arsen D. Ristić, Nebojsa Lalic, Petar M. Seferovic, Natasa Milic, Bosiljka Vujisic-Tesic, Milorad Tesic, Tanja Milicic, Ljiljana Lukic, Vojislav Giga, Aleksandra Jotic, Katarina Lalic |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty left ventricular diastolic dysfunction type 2 diabetes mellitus Myocardial Ischemia lcsh:Medicine 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Asymptomatic Prehypertension asymptomatic cardiovascular manifestations Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Tissue Doppler echocardiography Diabetes mellitus Internal medicine medicine Humans business.industry lcsh:R Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease silent myocardial ischemia 3. Good health Metformin Blood pressure Diabetes Mellitus Type 2 Cardiology Female medicine.symptom business medicine.drug |
| Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 139, Iss 9-10, Pp 599-604 (2011) Europe PubMed Central |
| ISSN: | 2406-0895 0370-8179 |
| DOI: | 10.2298/sarh1110599s |
| Popis: | Introduction. Several cardiovascular manifestations in patients with diabetes may be asymptomatic. Left ventricular diastolic dysfunction (LVDD) is considered to be the earliest metabolic myocardial lesion in these patients, and can be diagnosed with tissue Doppler echocardiography. Silent myocardial ischemia (SMI) is a characteristic and frequently described form of ischemic heart disease in patients with diabetes. Objective. The aim of the study was to assess the prevalence of LVDD and SMI in patients with type 2 diabetes, as well as to compare demographic, clinical, and metabolic data among defined groups (patients with LVDD, patients with SMI and patients with type 2 diabetes, without LVDD and SMI). Methods. We investigated 104 type 2 diabetic patients (mean age 55.4±9.1 years, 64.4% males) with normal blood pressure, prehypertension and arterial hypertension stage I. Study design included basic laboratory assessment and cardiological workup (transthoracic echocardiography and tissue Doppler, as well as the exercise stress echocardiography). Results. LVDD was diagnosed in twelve patients (11.5%), while SMI was revealed in six patients (5.8%). Less patients with LVDD were using metformin, in comparison to other two groups (χ2 =12.152; p=0.002). Values of HDL cholesterol (F=4.515; p=0.013) and apolipoprotein A1 (F=5.128; p= 0.008) were significantly higher in patients with LVDD. Conclusion. The study confirmed asymptomatic cardiovascular complications in 17.3% patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
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