Acute and Chronic Complications in Breast Cancer Patients Treated with Intraoperative Radiation Therapy
| Autor: | Peter Chen, Colleen Coleman, Cristina de Leon, Ralph Mackintosh, Lisa Guerra, Lincoln Snyder, Melvin J. Silverstein, Melinda Epstein, Kevin Lin, Sadia Khan, January Lopez, Brian S. Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Brachytherapy Breast Neoplasms Mastectomy Segmental 030218 nuclear medicine & medical imaging Necrosis 03 medical and health sciences 0302 clinical medicine Breast cancer Hyperpigmentation medicine Humans Surgical Wound Infection Prospective Studies Intraoperative radiation therapy Aged Retrospective Studies Aged 80 and over Hematoma Intraoperative Care business.industry Retrospective cohort study Middle Aged medicine.disease Fibrosis Surgery Radiation therapy Seroma Oncology Erythema 030220 oncology & carcinogenesis Acute Disease Chronic Disease Female Radiology Complication business Mastectomy |
| Zdroj: | Annals of Surgical Oncology. 23:3304-3309 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-016-5316-y |
| Popis: | Intraoperative radiation therapy (IORT) permits the delivery of radiation therapy directly to the tumor bed at the time of surgery. Minimal data are available about the complications associated with this modality of treatment using the Xoft(®) Axxent Electronic Brachytherapy (Axxent) System.A total of 702 patients who received IORT using the Xoft(®) Axxent System at Hoag Memorial Hospital Presbyterian between June 2010-February 2016 were accrued in an IORT data registry study. The prospective and retrospective protocols were approved by the institutional review board and met the guidelines of their responsible governmental agency. Data were collected at 1 week, 1 month, 3 months, 6 months, 1 year, and thereafter yearly. Acute complications were defined as those occurring within the first month. Chronic complications were those that persisted beyond 6 months.Acute complications were observed in 21 % of patients and included hematomas that required drainage, seromas requiring drainage more than 3 times, infections treated with antibiotics or surgery, necrosis requiring surgery, and erythema. Chronic complications were observed in 13 % of patients and included seromas, fibrosis, and hyperpigmentation. The majority of acute and chronic problems from IORT were mild. If grade I erythema, fibrosis, and hyperpigmentation were removed, only 32 of 702 (4.6 %) had significant complications. Our complication rates were comparable to those of the TARGIT trial.IORT is a modality that safely delivers radiation therapy to patients diagnosed with breast cancer. This technique allows women who cannot (or decline to) undergo whole breast radiation to consider breast-conserving therapy rather than mastectomy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink