Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

Autor:	Ibrahim Yakoub-Agha, Lars P. Ryder, Ib Jarle Christensen, Stephanie Thiant, Katrine Kielsen, Wendy Decker, Klaus Müller, Zaiba Shamim, Sylvie Faucher
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine Adolescent T-Lymphocytes medicine.medical_treatment Immunology Graft vs Host Disease Biology Polymorphism Single Nucleotide Interleukin-7 Receptor alpha Subunit Young Adult 03 medical and health sciences immune system diseases hemic and lymphatic diseases Genotype medicine Humans Transplantation Homologous Immunology and Allergy Mortality Allele Child Receptor Interleukin-7 receptor Aged Leukemia Interleukin-7 Lymphoma Non-Hodgkin Hematopoietic Stem Cell Transplantation Infant Middle Aged Myelodysplastic-Myeloproliferative Diseases Transplantation Haematopoiesis 030104 developmental biology Cytokine Child Preschool Acute Disease Female Stem cell Thrombocythemia Essential
Zdroj:	Clinical Immunology. 187:26-32
ISSN:	1521-6616
Popis:	Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R. The sIL-7Rα levels decreased during HSCT (from 114ng/ml before to 48ng/ml at day +14 (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badbce7d6d8090f0b2122134530824e7 https://doi.org/10.1016/j.clim.2017.08.015 Zobrazit plný text záznamu Full Text from ScienceDirect