An update on the H blood group system
| Autor: | Coral Olsen, Peter Bugert, Erwin A. Scharberg |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood transfusion
Fucosyltransferase biology medicine.medical_treatment Hematology General Medicine H antigen Fucosyltransferases Null allele Molecular biology Fucose ABO Blood-Group System Gene product Medical Laboratory Technology chemistry.chemical_compound Phenotype chemistry Antigen ABO blood group system medicine biology.protein Humans Immunology and Allergy Alleles |
| Zdroj: | Immunohematology. 35:67-68 |
| ISSN: | 1930-3955 |
| DOI: | 10.21307/immunohematology-2020-017 |
| Popis: | This update of the H blood group system (Scharberg EA, Olsen C, Bugert P. The H blood group system. Immunohematology 2016;32:112–8) reports 11 new FUT1 null alleles: 8 causative for the H– phenotype (Bombay phenotype, Oh), 3 in para-Bombay cases, and 5 new FUT1 alleles causative for a weak H phenotype (para-Bombay, H+w). The H blood group system (International Society of Blood Transfusion system 18) consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells (RBCs) and in secretions. The H antigen is synthesized on the RBC surface by the FUT1 gene product fucosyltransferase 1. On epithelial cells and in body fluids, the H antigen is synthesized by the FUT2 gene product fucosyltransferase 2. |
| Databáze: | OpenAIRE |
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