A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth
| Autor: | Stacey A. Kalovidouris, Linda C. Hsieh-Wilson, Lori W. Lee, Cristal I. Gama |
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| Rok vydání: | 2005 |
| Předmět: |
Biotin
Hippocampal formation Neurotransmission Disaccharides Hippocampus Biochemistry Catalysis Fucose Epitopes chemistry.chemical_compound Colloid and Surface Chemistry Lectins Neurites Humans Receptor Neurons chemistry.chemical_classification biology Chemistry Galactose Lectin General Chemistry Receptors Mitogen Synaptic plasticity biology.protein Glycoprotein |
| Zdroj: | Journal of the American Chemical Society. 127:1340-1341 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja044631v |
| Popis: | We report a fucose alpha(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucalpha(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucalpha(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration. |
| Databáze: | OpenAIRE |
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