Utility of methyl 2-isothiocyanatobenzoate in the synthesis of some new quinazoline derivatives as potential anticancer and radiosensitizing agents
| Autor: | Ahmad A. Bayomi, Helmi I. Heiba, Mostafa M. Ghorab, Fatma A. Ragab |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Radiation-Sensitizing Agents
Magnetic Resonance Spectroscopy Combination therapy Spectrophotometry Infrared Antineoplastic Agents Benzoates Cell Line Cell Line Tumor Drug Discovery medicine Humans Doxorubicin chemistry.chemical_classification Biological activity Combinatorial chemistry Survival Analysis In vitro Sulfonamide Cell killing chemistry Liver Cell culture Gamma Rays Quinazolines Radiosensitizing Agent Indicators and Reagents Drug Screening Assays Antitumor Thiocyanates medicine.drug |
| Zdroj: | Arzneimittel-Forschung. 61(12) |
| ISSN: | 0004-4172 |
| Popis: | Novel quinazolines 4-11, 15 and triazoloquinazolines 12-14 bearing biologically active sulfonamide moieties were synthesized. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against liver cancer cell line (HEPG2). Some of the screened compounds exhibited interesting cytotoxic activity compared to doxorubicin as a reference drug. The most active compounds 13 and 15 were selected and evaluated for their ability to enhance the cell killing effect of gamma-radiation, compound 15 was superior to doxorubicin in radiation combination therapy. |
| Databáze: | OpenAIRE |
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