p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia

Autor:	Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Rok vydání:	2022
Předmět:	Cellular and Molecular Neuroscience Amyloid beta-Peptides Neurology Alzheimer Disease Interleukin-6 Neuroscience (miscellaneous) Humans Plaque Amyloid Microglia p38 Mitogen-Activated Protein Kinases
Zdroj:	Molecular neurobiology. 59(9)
ISSN:	1559-1182
Popis:	The accumulation of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD) pathology. Microglial activation-mediated neuroinflammation has been implicated in the pathogenesis of AD and the expression levels of interleukin-6 (IL-6) were increased in the brains of AD patients. However, the mechanisms by which IL-6 expression is regulated in human microglia are incompletely understood. Here, we show that Aβ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad4a097883bd95c463b1069027a02ad https://pubmed.ncbi.nlm.nih.gov/35697992 Zobrazit plný text záznamu Full text from SpringerLink