Antibacterial Activity of Amidodithiophosphonato Nickel(II) Complexes: An Experimental and Theoretical Approach
| Autor: | Vito Lippolis, Antonella Ibba, Enrico Podda, M. Carla Aragoni, Germano Orrù, Francesco Isaia, James B. Orton, Enrica Tuveri, Giulia Atzeni, Anna Pintus, Simon J. Coles, Massimiliano Arca |
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| Rok vydání: | 2020 |
| Předmět: |
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Molecular Chemistry Pharmaceutical Pharmaceutical Science Ligands 01 natural sciences Medicinal chemistry Analytical Chemistry chemistry.chemical_compound density functional theory (DFT) Benzylamine antibacterial activity Coordination Complexes Nickel Spectroscopy Fourier Transform Infrared Drug Discovery Candida Hydrolysis Phosphorus Anti-Bacterial Agents Chemistry (miscellaneous) Molecular Medicine Density functional theory Antibacterial activity Escherichia Staphylococcus aureus Nitrogen amidodithiophosphonate chemistry.chemical_element Microbial Sensitivity Tests 010402 general chemistry Article lcsh:QD241-441 lcsh:Organic chemistry Pseudomonas Physical and Theoretical Chemistry P–N cleavage Bond cleavage 010405 organic chemistry Organic Chemistry Staphylococcus haemolyticus X-ray diffraction 0104 chemical sciences chemistry Biofilms Drug Design Reagent Yield (chemistry) Quantum Theory nickel complexes |
| Zdroj: | Molecules Volume 25 Issue 9 Molecules, Vol 25, Iss 2052, p 2052 (2020) |
| ISSN: | 1420-3049 |
| Popis: | The reactions of 2,4-bis(4-methoxyphenyl)-1,3-dithio-2,4-diphosphetane-2,4-disulfide (Lawesson&rsquo s Reagent, LR) with benzylamine (BzNH2) and 4-phenylbutylamine (PhBuNH2) yield benzylammonium P-(4-methoxyphenyl)-N-benzyl-amidodithiophosphonate (BzNH3)(BzNH-adtp) and 4-phenylbutylammonium P-(4-methoxyphenyl)-N-(4-phenylbutyl)-amidodithiophosphonate (PhBuNH3)(PhBuNH-adtp). The relevant nickel complexes [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] and the corresponding hydrolysed derivatives (BzNH3)2[Ni(dtp)2] and (PhBuNH3)2[Ni(dtp)2] were prepared and fully characterized. The antimicrobial activity of the aforementioned amidodithiophosphonates against a set of Gram-positive and Gram-negative pathogen bacteria was evaluated, and [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] showed antiproliferative activity towards Staphylococcus aureus and Staphylococcus haemolyticus strains. density functional theory (DFT) calculations were performed to shed some light on the activity of reported compounds related to their tendency towards P&ndash N bond cleavage. |
| Databáze: | OpenAIRE |
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