The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
| Autor: | Janine T. Erler, Alison Gartland, Thomas R. Cox |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cell type lcsh:Diseases of the musculoskeletal system business.industry Cancer Bone metastasis Pre-metastatic niche Lysyl oxidase Metastatic bone tumour medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Metastasis Extracellular matrix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine lcsh:RC925-935 business Research Paper |
| Zdroj: | Journal of Bone Oncology, Vol 5, Iss 3, Pp 100-103 (2016) Journal of Bone Oncology |
| ISSN: | 2212-1374 |
| Popis: | Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis |
| Databáze: | OpenAIRE |
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