Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates
| Autor: | Adam Nelson, Emily L Faulkner, Alexandre F. Trindade, Andrew G. Leach, Stephen P. Marsden |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Fragment (computer graphics) Chemistry Metals and Alloys Regioselectivity Halide Photoredox catalysis General Chemistry 010402 general chemistry Electrochemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Materials Chemistry Ceramics and Composites Amine gas treating Alkyl Cyclic amines |
| Zdroj: | Trindade, A F, Faulkner, E L, Leach, A G, Nelson, A & Marsden, S P 2020, ' Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates ', Chemical communications (Cambridge, England) . https://doi.org/10.1039/d0cc03934a |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d0cc03934a |
| Popis: | A strategy for the β-sp3 functionalisation of cyclic amines is described. Regioselective conversion of protected amines to enecarbamates is achieved through electrochemical oxidation; these intermediates can be derivatised by functionalised alkyl halides under photoredox catalysis. The potential of the methods is highlighted by direct growth of a DCP2B-binding fragment. |
| Databáze: | OpenAIRE |
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