Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars
| Autor: | Bo Xiao, Jianfei Zhang, Zheng Li, Kaige Hao, Lian Liu, Baiqing Wu, Xinyue Zheng, Fangyin Dai, Jiangbo Song, Xiaoling Tong |
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| Rok vydání: | 2019 |
| Předmět: |
Biocompatibility
Cicatrix Hypertrophic Surface Properties Fibroin Scars 02 engineering and technology Pharmacology 01 natural sciences Hypertrophic scar Colloid and Surface Chemistry 0103 physical sciences medicine Animals Physical and Theoretical Chemistry Particle Size 010304 chemical physics business.industry Therapeutic effect Ear Hydrogels Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology medicine.disease Self-healing hydrogels Hypertrophic scars Rabbits medicine.symptom 0210 nano-technology Wound healing business Fibroins Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 186 |
| ISSN: | 1873-4367 |
| Popis: | Current medications for the treatment of hypertrophic scars suffer from bottlenecks of limited therapeutic efficacy and a slow recovery rate. Silk fibroin (SF) has gained attention for its ability to promote wound healing in burns and cutaneous wounds, but its therapeutic effects against hypertrophic scar have not been thoroughly investigated. We prepared SF-based hydrogels (SFHs) with various SF concentrations (1.5 %, 3 %, and 6 %) and characterized their physicochemical properties. Cell experiments showed that these SFHs had favorable biocompatibility in vitro. Further animal experiments in rabbits revealed that the SFH (3 %)-treated group achieved scars on their ears that were thinner and significantly lighter in color compared with the negative control group. Moreover, treatment with SFHs reduced the density and led to the orderly arrangement of collagen fibers. It was found that the therapeutic effects of SFHs were attributed to the reduced expression levels of α-smooth muscle actin. These results are the first to demonstrate that SFH can be exploited as an effective therapeutic agent for the treatment of hypertrophic scars. |
| Databáze: | OpenAIRE |
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