Milling-Induced Disorder of Pharmaceuticals: One-Phase or Two-Phase System?
| Autor: | Brian S. Luisi, Brian Moulton, Zhouyuan Liu, Ales Medek, Praveen Mudunuri |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Magnetic Resonance Spectroscopy
Materials science Calorimetry Differential Scanning Drug Compounding Indomethacin Pharmaceutical Science Thermodynamics Crystallographic defect Phase Transition Amorphous solid Crystallography Glucosides X-Ray Diffraction Polyamorphism Ultimate tensile strength sense organs Crystallization Benzyl Alcohols |
| Zdroj: | Journal of Pharmaceutical Sciences. 101:1475-1485 |
| ISSN: | 0022-3549 |
| Popis: | During milling, components are subjected to shear and tensile stresses, which can result in physical phase transformations. The purpose of the work described in this report is to understand the pathway by which two test compounds, d -salicin and γ-indomethacin, undergo a crystalline to amorphous transformation during cryomilling. The results show that the transformation cannot be described by a standard one-phase or two-phase disordering mechanism. In the one-phase model, a continuous set of states exist, linking perfect crystalline with completely amorphous material, whereas the two-phase model of disorder depicts the material as a binary mixture of crystalline and amorphous fractions. Instead, a model is proposed where two one-phase regions, defected crystalline and amorphous regions, are separated by a distinct transition. |
| Databáze: | OpenAIRE |
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