Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam
| Autor: | Huy Q. Vu, Hai Duc Nguyen, Lan T. Phan, Cuong Q. Hoang, Thang D Tat, Linh Thuy Hoang, Khai T Nguyen, Hong Ly |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Tenofovir Article Subject 030232 urology & nephrology Renal function HIV Infections General Biochemistry Genetics and Molecular Biology Serology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine medicine Prevalence Hiv infected patients Humans 030212 general & internal medicine Creatinine General Immunology and Microbiology business.industry Isoniazid General Medicine Middle Aged Regimen Cross-Sectional Studies chemistry Anti-Retroviral Agents Vietnam HIV-1 Medicine Female Kidney Diseases business medicine.drug Research Article |
| Zdroj: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Background. The situation of renal impairment among HIV-infected patients treated with TDF-based antiretroviral (ARV) regimen greater than 3 years is little known when TDF use has been promptly increasing in Vietnam.Methods. We analyse demographic and clinical data from a cross-sectional survey of 400 HIV-infected patients aged ≥18 years, who were treatment-naive or switched TDF regimen within over 3 years between November 2018 and March 2019. Serological tests for serum creatinine, ALT, and AST were performed. Renal impairment was defined as an estimated glomerular filtration rate (eGFR) 2. Multivariate regression analyses were used to explore the risk factors associated with renal impairment.Results. At the baseline, 7.8% of respondents had estimated glomerular filtration rate (eGFR) of 30–59 mL/min/1.73 m2and 0.8% had eGFR of 15–29 mL/min/1.73 m2, out of 34 (8.5%) of participants who had renal impairment. Multivariate analysis showed that participants who had preexposure to isoniazid (adjusted PR [aPR] = 0.35 Cl: 0.14–0.91) compared with nonexposure to isoniazid who had a BMI from 18.5 up to 25 kg/m2(aPR = 0.31 Cl: 0.15–0.62) compared with BMI below 18.5 kg/m2were less likely to suffer from renal impairment. Patients aged greater than 60 years (aPR = 26.75, 95% Cl: 3.38–211.62) compared with those aged 20–29 years were more likely to have increased risk of renal impairment.Conclusion. Our findings underscore the need for longitudinal studies to assess the influence of TDF on maintaining the low prevalence of renal impairment among HIV-infected patients in Vietnam. |
| Databáze: | OpenAIRE |
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