The Expression and Function of Circadian Rhythm Genes in Hepatocellular Carcinoma
| Autor: | Hai Feng, Lu Chai, Shucai Yang, Yanan Jiang, Yue Ou, Ying Liu, Moyondafoluwa Blessing Fasae, Siwei Liu, Xiuyun Shen, Fengnan Zhi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aging
Carcinoma Hepatocellular Time Factors Antineoplastic Agents Review Article Biochemistry medicine Biomarkers Tumor Animals Humans Gene Regulatory Networks Circadian rhythm Gene neoplasms QH573-671 Mechanism (biology) business.industry Circadian Rhythm Signaling Peptides and Proteins Drug Chronotherapy Liver Neoplasms Cancer Diagnostic marker Cell Biology General Medicine medicine.disease Prognosis digestive system diseases Circadian Rhythm Gene Expression Regulation Neoplastic Hepatocellular carcinoma Cancer research Cytology business Function (biology) Signal Transduction |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Hepatocellular carcinoma (HCC) is among the most common and lethal form of cancer worldwide. However, its diagnosis and treatment are still dissatisfactory, due to limitations in the understanding of its pathogenic mechanism. Therefore, it is important to elucidate the molecular mechanisms and identify novel therapeutic targets for HCC. Circadian rhythm-related genes control a variety of biological processes. These genes play pivotal roles in the initiation and progression of HCC and are potential diagnostic markers and therapeutic targets. This review gives an update on the research progress of circadian rhythms, their effects on the initiation, progression, and prognosis of HCC, in a bid to provide new insights for the research and treatment of HCC. |
| Databáze: | OpenAIRE |
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