Monitoring CP-93,393 reaction mixtures by flow-injection analysis-mass spectrometry

Autor:	R.H. Reed, Stephen T. Colgan, P.D. Hammen, T.R. Sharp, P.W. Gwiazda, G.J. Horan
Rok vydání:	1996
Předmět:	Flow injection analysis Solvent Chromatography Molecular mass Chemistry Drug candidate Selected reaction monitoring Analytical chemistry Atmospheric-pressure chemical ionization Mass spectrometry Quantitative analysis (chemistry) Analytical Chemistry
Zdroj:	Talanta. 43:851-857
ISSN:	0039-9140
DOI:	10.1016/0039-9140(95)01816-6
Popis:	CP-93,393 is a drug candidate at Pfizer. Flow-injection analysis-mass spectrometry (FIA-MS) was used to monitor reaction completion for CP-93,393 reaction mixtures. FIA-MS provides essentially instantaneous results, is relatively simple to operate, and is a universal system that can be used to monitor any reaction as long as the product has a molecular weight that differs from the molecular weights of the reactants. The mass spectrometer for these studies employed atmospheric pressure chemical ionization. Samples were introduced into the mass spectrometer with a flowing stream of solvent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baccf03f2b386e53e91c84a38ca6c5b5 https://doi.org/10.1016/0039-9140(95)01816-6 Zobrazit plný text záznamu Full Text from ScienceDirect