Trilineage Phenotypic Compromise in Acute Leukemia

Autor:	Federico R Ramírez, Maria M.E. de Bracco, M. V. Castuma, María Fernanda Palacios, Mariano Scolnik, R. Tur
Rok vydání:	1999
Předmět:	Adult Male Cancer Research medicine.medical_specialty Acute leukemia Myeloid Acute Biphenotypic Leukemia Cytogenetics Cell Separation Hematology Biology Flow Cytometry Phenotype Leukemia Myeloid Acute Fatal Outcome medicine.anatomical_structure Immunophenotyping Oncology Antigen hemic and lymphatic diseases Immunology medicine Humans Sudan black
Zdroj:	Leukemia & Lymphoma. 34:395-399
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428199909050965
Popis:	The expression of three lineage specific antigens in the leukemic blasts is extremely infrequent. We here report a case of triphenotypic acute leukemia with involvement of the myeloid and B and T lineages. The morphology of the blasts showed promyelocytic features with agranular cytoplasm, suggesting a M3-variant of AML. The blasts were positive for myeloperoxidase PAS and Sudan Black. Immunophenotype and cytogenetics did not confirm M3-AML diagnosis, showing a trilineage compromise (myeloid and T and B lymphoid markers) and the cytogenetic alterations +8 and +11, respectively. This report highlights the importance of correlating the results of multiple diagnostic methods in order to establish a correct diagnosis of mixed lineage acute leukemias, and allows evaluation of the prognostic importance of this subgroup of patients.
Databáze:	OpenAIRE
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