Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case–Control Study (CEFALO)
| Autor: | Tone Eggen, Claudia E. Kuehni, Denis Aydin, Birgitta Lannering, Martin Röösli, Aslak Harbo Poulsen, Joachim Schüz, Tore Tynes, Kjeld Schmiegelow, Lisbeth Samsø Schmidt, Lars Klaeboe, Maria Feychting, Michaela Prochazka, Tina Veje Andersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research Pediatrics medicine.medical_specialty Adolescent Epidemiology infectious disease Population 610 Medicine & health Scandinavian and Nordic Countries Infections 03 medical and health sciences Young Adult 0302 clinical medicine children 360 Social problems & social services Recall bias medicine Humans Interpersonal Relations Young adult education Child 030304 developmental biology 0303 health sciences education.field_of_study business.industry Brain Neoplasms social contact Case-control study Odds ratio Confidence interval 3. Good health childhood brain tumour Birth order Oncology 030220 oncology & carcinogenesis Case-Control Studies Female business Switzerland |
| Zdroj: | British Journal of Cancer British journal of cancer Andersen, T V; Schmidt, L S; Poulsen, A H; Feychting, M; Röösli, M; Tynes, T; Aydin, D; Prochazka, M; Lannering, B; Klæboe, L; Eggen, T; Kuehni, C E; Schmiegelow, K; Schüz, J (2013). Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case-Control Study (CEFALO). British journal of cancer, 108(11), pp. 2346-2353. Nature Publishing Group 10.1038/bjc.2013.201 |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2013.201 |
| Popis: | BACKGROUND Infectious diseases and social contacts in early life have been proposed to modulate brain tumour risk during late childhood and adolescence. METHODS CEFALO is an interview-based case-control study in Denmark, Norway, Sweden and Switzerland, including children and adolescents aged 7-19 years with primary intracranial brain tumours diagnosed between 2004 and 2008 and matched population controls. RESULTS The study included 352 cases (participation rate: 83%) and 646 controls (71%). There was no association with various measures of social contacts: daycare attendance, number of childhours at daycare, attending baby groups, birth order or living with other children. Cases of glioma and embryonal tumours had more frequent sick days with infections in the first 6 years of life compared with controls. In 7-19 year olds with 4+ monthly sick day, the respective odds ratios were 2.93 (95% confidence interval: 1.57-5.50) and 4.21 (95% confidence interval: 1.24-14.30). INTERPRETATION There was little support for the hypothesis that social contacts influence childhood and adolescent brain tumour risk. The association between reported sick days due to infections and risk of glioma and embryonal tumour may reflect involvement of immune functions, recall bias or inverse causality and deserve further attention. |
| Databáze: | OpenAIRE |
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