Preparation and evaluation of gel formulations for oral sustained delivery to dysphagic patients
| Autor: | Ryozo Mikami, Masatake Dairaku, Akie Takahashi, Kunihiko Itoh, David Attwood, Mariko Ishitani, Shozo Miyazaki, Mitsuo Togashi |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Drug food.ingredient Swine Chemistry Pharmaceutical media_common.quotation_subject Analgesic Drug Evaluation Preclinical Administration Oral Pharmaceutical Science Dentistry Gelatin Dosage form chemistry.chemical_compound Drug Delivery Systems food Oral administration Drug Discovery medicine Animals Antipyretic Rats Wistar Acetaminophen media_common Pharmacology Chromatography business.industry digestive oral and skin physiology Organic Chemistry Controlled release Rats Xyloglucan chemistry Delayed-Action Preparations Deglutition Disorders business Gels medicine.drug |
| Zdroj: | Drug Development and Industrial Pharmacy. 35:780-787 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639040802592443 |
| Popis: | Oral sustained release gel formulations may provide a means of administering drugs to dysphagic and geriatric patients who have difficulties with handling and taking oral dosage forms.We have designed gel formulations for the oral administration of paracetamol with suitable rheological characteristics for ease of administration to patients with swallowing difficulties and sufficient integrity in the acidic environment of the stomach to achieve a sustained release of this drug.Gels formed by gelatin, agar, gellan, pectin, and xyloglucan were assessed for suitable gel strength and in vitro and in vivo release characteristics.Gellan (1.5% w/v) and xyloglucan gels (1.5% w/w) had acceptable gel strengths for ease of swallowing and retained their integrity in the rat stomach sufficiently well to sustain the release of paracetamol over a period of 6 hours. Comparison of 1.5% xyloglucan gels with a commercially available preparation with identical paracetamol concentrations demonstrated improved sustained release properties of the xyloglucan gels.Gels formed by gellan and xyloglucan have suitable rheological and sustained release characteristics for potential use as vehicles for oral delivery of drugs to dysphagic patients. |
| Databáze: | OpenAIRE |
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