Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies
| Autor: | André Masse, Charles Marseille-Tremblay, Yves Giguère, Julie Lafond, Jean-Claude Forest, Emile Levy, Maude Ethier-Chiasson |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Embryology medicine.medical_specialty Low-density lipoprotein receptor-related protein 8 Placenta Blotting Western Hypercholesterolemia medicine.disease_cause Body Mass Index Endocrinology Pregnancy Internal medicine Hyperlipidemia medicine OLR1 Humans Receptor Labor Obstetric medicine.diagnostic_test business.industry Infant Newborn Obstetrics and Gynecology Cell Biology medicine.disease Scavenger Receptors Class E Immunohistochemistry Pregnancy Complications Diabetes Gestational Cholesterol Reproductive Medicine Cytokines Female Lipid profile business Oxidative stress Lipoprotein |
| Zdroj: | Reproduction (Cambridge, England). 136(4) |
| ISSN: | 1741-7899 |
| Popis: | The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (OLR1) is a newly described receptor for oxidatively modified LDL. The human pregnancy is associated with hyperlipidemia and oxidative stress. It has been reported that modification in maternal lipid profile can induce disturbance during pregnancy. In this study, we have evaluated the expression protein level of OLR1 in human term placenta of women having plasma cholesterol level lower to 7 mM or higher to 8 mM and women of gestational diabetes mellitus (GDM) by western blot analysis. The present study demonstrates that the maternal lipid profile is associated with placental protein expression of OLR1. A significant increase in the protein expression of OLR1 was observed in placenta of women with elevated plasmatic total cholesterol level (>8 mM). In addition, the placental protein expression of OLR1 is increased in mothers having the highest pre-pregnancy body mass index (BMI) and low ( |
| Databáze: | OpenAIRE |
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