Varicella-related deaths in children and adolescents--Germany 2003-2004
| Autor: | Veit Grote, Johannes G. Liese, Gerhard Hammersen, Wolfgang Springer, Hans Wolfgang Kreth, Rüdiger von Kries |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Myocarditis Adolescent viruses Population Congenital Varicella Syndrome Chickenpox Germany Epidemiology Medicine Humans education Child Cause of death education.field_of_study integumentary system business.industry Public health Mortality rate virus diseases Infant General Medicine medicine.disease El Niño Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 97(2) |
| ISSN: | 0803-5253 |
| Popis: | Aim: Although varicella is acknowledged as a rare cause of death in children, there are few comprehensive data with respect to the clinical course leading to death. Methods: A nationwide, active surveillance was carried out in Germany for children up to age 17 years who were admitted to a paediatric hospital for varicella or associated complications, including deaths. Results: A total of 10 children with varicella-associated death were reported over period of 2 years, yielding a mortality rate of 0.4/1 000 000 children per year. Three deaths occurred in children diagnosed with acute lymphocytic leukaemia and disseminated varicella, two shortly after diagnosis of leukaemia and therefore not preventable, and one during remission with an untypical presentation. Two children died with a congenital varicella syndrome. There was no death in children with neonatal varicella. Four other cases were related to varicella pneumonia or septicaemia and one to myocarditis. Conclusion: In a population with no general varicella vaccination programme, varicella accounted for a small but not negligible risk for death in immunocompetent and immunocompromised children. Together these data point to the importance of a thoroughly implemented, general varicella vaccination programme. |
| Databáze: | OpenAIRE |
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