Absence of a pharmacokinetic interaction between digoxin and levofloxacin
| Autor: | J Natarajan, M C Rogge, S C Chien, A T Chow, F Wong, R R Williams |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Digoxin Ofloxacin Adolescent Cmax Administration Oral Biological Availability Levofloxacin Pharmacology Placebos Therapeutic index Anti-Infective Agents Double-Blind Method Pharmacokinetics Oral administration polycyclic compounds Humans Medicine Drug Interactions heterocyclic compounds Pharmacology (medical) cardiovascular diseases Antibacterial agent Cross-Over Studies business.industry digestive oral and skin physiology Middle Aged biochemical phenomena metabolism and nutrition Crossover study Kinetics Area Under Curve Female business medicine.drug |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 27:7-12 |
| ISSN: | 1365-2710 0269-4727 |
| DOI: | 10.1046/j.1365-2710.2002.00388.x |
| Popis: | Background: Levofloxacin, a broad-spectrum fluoroquinolone, may enhance digoxin bioavailability by eliminating intestinal flora that metabolize digoxin. Moreover, levofloxacin, which is eliminated primarily by glomerular filtration and active tubular secretion, may alter the elimination rate of digoxin. Because of the narrow therapeutic index of digoxin, it is important to evaluate the potential for interaction with levofloxacin when administered concomitantly. Methods: This was a placebo-controlled, randomized, double-blind, two-phase crossover study. Twelve healthy subjects (six males and six females) received 500 mg twice/day oral doses of levofloxacin or placebo for 6 days and a single oral dose of 0·4 mg digoxin on the morning of study day 5 along with levofloxacin or placebo. Results: There was no significant effect of levofloxacin on the pharmacokinetics (Cmax, AUC, and other disposition parameters) of oral digoxin. Steady-state levofloxacin absorption and disposition kinetics were also similar in the presence or absence of digoxin. Conclusions: Results of this study suggest that an important pharmacokinetic interaction between levofloxacin and digoxin is unlikely to occur when administered concomitantly. |
| Databáze: | OpenAIRE |
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