Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations
| Autor: | Elena M. Fedorova, Yulia V. Shilenkova, Igor Yu. Kogan, Olga E. Talantova, Alexander M. Gzgzyan, Mariia A. Ishchuk, Lubov’ I. Petrova, Anna A. Pendina, Elena A. Lesik, Evgeniia M. Komarova, Irina D. Mekina, Olga G. Chiryaeva, Olga A. Efimova, Vera S. Dudkina |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Anti-Mullerian Hormone Heterozygote Serum fsh anti-Müllerian hormone (AMH) lcsh:QH426-470 Robertsonian translocation Oocyte Retrieval Chromosomal translocation Controlled ovarian hyperstimulation Biology medicine.disease_cause Translocation Genetic Article Fsh levels Andrology 03 medical and health sciences 0302 clinical medicine PGT-SR Ovulation Induction Genetics medicine Humans follicle-stimulating hormone (FSH) translocation carriers Genetics (clinical) Retrospective Studies 030219 obstetrics & reproductive medicine Age Factors Oocyte Predictive value lcsh:Genetics female age 030104 developmental biology medicine.anatomical_structure Treatment Outcome IVF Female Follicle Stimulating Hormone Infertility Female Hormone |
| Zdroj: | Genes Volume 12 Issue 1 Genes, Vol 12, Iss 18, p 18 (2021) |
| ISSN: | 2073-4425 |
| Popis: | We studied the impact of age and the serum anti-Mü llerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus&ndash oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman&rsquo s age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either < 35 or &ge 35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups the correlation was strong positive in reciprocal and moderate positive in Robertsonian translocation carriers. The 46,XX women aged both < 35 and &ge 35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged < 35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translocation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers. |
| Databáze: | OpenAIRE |
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